We are also experiencing this issue and it started a couple weeks ago but was only impacting one user now we seem to have multiple users being impacted.
One of our engineers who has been working with Genesys on this received this update from them this morning:
"Chrome released a new experimental flag into the stable channel release that caused audio processing to be blocked in background windows. With the way the salesforce integration works (with the WebRTC pop up window), we believe this could have been causing some issues."
So far the workaround for us has been to have the users use Edge browser and make sure pop-ups are allowed.
------------------------------
Jimmy Ortiz
Edelman Financial Engines, LLC
------------------------------