HI Mahesh
Unfortunately, that's not possible.
The documentation states that even with the option disabled at the org level, the user will still be able to use it.
https://help.genesys.cloud/articles/enable-multi-factor-authentication/

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Kaio Oliveira
GCP - GCQM - GCS - GCA - GCD - GCO - GPE & GPR - GCWM
PS.: I apologize if there are any mistakes in my English; my primary language is Portuguese-Br.
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