Are agents logging in via browser, or the desktop client? When they create a new profile, are they setting and saving which device to use, and running the Diagnostics to see if there are any problems?
If none of those things helps preserve the settings from session to session, you should probably open a Care case to get it properly documented and start the process of getting it diagnosed.
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George Ganahl CCXP, GCA
Principal Technology Consultant
Genesys
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